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Updated: Jul 11, 2026

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

Lupus nephritis. Clinicopathological correlation.

Ibrahim H Al-Zahrani¹, Azhar Qayyum

¹Department of Pathology, College of Medicine, King Abdul-Aziz University Hospital, Jeddah, Kingdom of Saudi Arabia.

Saudi Medical Journal

|October 5, 2007

Summary

This summary is machine-generated.

Renal biopsies classified lupus nephritis, with WHO class IV being most common. Biopsy findings significantly improved clinical status prediction, though direct correlation with clinical features varied.

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Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

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Published on: December 30, 2025

Area of Science:

Nephrology
Pathology
Immunology

Background:

Lupus nephritis is a severe complication of systemic lupus erythematosus.
Accurate classification of lupus nephritis is crucial for prognosis and treatment.
Histopathological evaluation of renal biopsies is key to understanding disease activity.

Purpose of the Study:

Classify lupus nephritis renal biopsies using the modified World Health Organization (WHO) classification.
Assess activity and chronicity indices using the National Institute of Health (NIH) protocol.
Correlate histological findings with clinical features at the time of biopsy.

Main Methods:

Retrospective review of 78 lupus nephritis patients' renal biopsies.
Biopsies analyzed over a 10-year period (1995-2005).
Utilized light, fluorescent, and electron microscopy; assessed by histopathologists and a nephrologist.

Main Results:

WHO class IV was the predominant histological type.
Class IV patients frequently presented with microhematuria, proteinuria, and renal insufficiency.
Active and chronic lesions were more common in classes III/IV, correlating with clinical renal disease evidence.

Conclusions:

Renal biopsy findings significantly enhance the prediction of lupus nephritis patient status.
While a relationship exists between histopathology and clinical course, uniform correlation was not observed.
Renal biopsy provides critical information beyond clinical data for managing lupus nephritis.