Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Stability of Substituted Cyclohexanes02:30

Stability of Substituted Cyclohexanes

This lesson discusses the stability of substituted cyclohexanes with a focus on energies of various conformers and the effect of 1,3-diaxial interactions.
The two chair conformations of cyclohexanes undergo rapid interconversion at room temperature. Both forms have identical energies and stabilities, each comprising equal amounts of the equilibrium mixture. Replacing a hydrogen atom with a functional group makes the two conformations energetically non-equivalent.
For example, in...
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism01:21

Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism

Polymorphism refers to the existence of a drug substance in multiple crystalline forms, known as polymorphs. Recently, this term has been expanded to include solvates (forms containing a solvent), amorphous forms (non-crystalline forms), and desolvated solvates (forms from which the solvent has been removed).
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeted IL-4 nanoparticles for osteal macrophages modulation in osteoporosis.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences·2026
Same author

ADAM: advanced design and AI-driven modeling for plant tissue culture media optimization.

Plant methods·2026
Same author

3D-printed chitosan-starch mesh filled with minocycline-alginate hydrogel for dual anti-Staphylococcus aureus and osteogenic effects.

Carbohydrate polymers·2025
Same author

Novel Core-Shell Aerogel Formulation for Drug Delivery Based on Alginate and Konjac Glucomannan: Rational Design Using Artificial Intelligence Tools.

Polymers·2025
Same author

Design of Clofazimine-Loaded Lipid Nanoparticles Using Smart Pharmaceutical Technology Approaches.

Pharmaceutics·2025
Same author

Correction to "Praziquantel Nanoparticle Formulation for the Treatment of Schistosomiasis".

ACS applied nano materials·2025

Related Experiment Video

Updated: Jul 11, 2026

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
11:27

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients

Published on: August 9, 2022

Characterization of beta-lapachone and methylated beta-cyclodextrin solid-state systems.

Marcílio S S Cunha-Filho1, Bruno Dacunha-Marinho, Juan J Torres-Labandeira

  • 1Departamento de Farmacia y Tecnología Farmacéutica, Facultad de Farmacia, Universidad de Santiago de Compostela, Santiago de Compostela, 15782, Spain.

AAPS Pharmscitech
|October 6, 2007
PubMed
Summary

Randomly methylated-beta-cyclodextrin (RMbetaCD) effectively enhanced the water solubility and dissolution of the antitumoral drug beta-lapachone (betaLAP). The kneading method produced optimal RMbetaCD/betaLAP inclusion complexes for pharmaceutical applications.

More Related Videos

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
10:10

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Published on: August 15, 2016

Biomembrane Fabrication by the Solvent-assisted Lipid Bilayer (SALB) Method
09:38

Biomembrane Fabrication by the Solvent-assisted Lipid Bilayer (SALB) Method

Published on: December 1, 2015

Related Experiment Videos

Last Updated: Jul 11, 2026

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients
11:27

A Package of Established Analytical Tools to Investigate the Solid-State Alteration of Lipid-Based Excipients

Published on: August 9, 2022

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
10:10

Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

Published on: August 15, 2016

Biomembrane Fabrication by the Solvent-assisted Lipid Bilayer (SALB) Method
09:38

Biomembrane Fabrication by the Solvent-assisted Lipid Bilayer (SALB) Method

Published on: December 1, 2015

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science
  • Drug Delivery

Background:

  • Beta-lapachone (betaLAP) is an antitumoral drug with poor water solubility, limiting its therapeutic efficacy.
  • Cyclodextrins, including beta-cyclodextrin (betaCD) and its derivatives, are known to improve the solubility of poorly soluble drugs.
  • Developing stable and effective formulations is crucial for enhancing betaLAP's bioavailability.

Purpose of the Study:

  • To investigate the potential of beta-cyclodextrin (betaCD) and its derivatives (HPbetaCD, SBbetaCD, RMbetaCD) in forming inclusion complexes with beta-lapachone (betaLAP).
  • To overcome the poor water solubility of betaLAP through complexation.
  • To evaluate and compare the efficiency of different betaCD derivatives and preparation methods for betaLAP inclusion complex formation.

Main Methods:

  • Screening of various beta-cyclodextrin derivatives (HPbetaCD, SBbetaCD, RMbetaCD) for betaLAP solubilization.
  • Preparation of solid-state binary systems using freeze-drying and kneading techniques.
  • Characterization of inclusion complexes using Differential Scanning Calorimetry (DSC), X-ray Powder Diffractometry (XRPD), Fourier Transform Infrared Spectroscopy (FTIR), and microscopy (optical and scanning electron).
  • Assessment of drug dissolution efficiency (DE(20-minute)).

Main Results:

  • Randomly methylated-beta-cyclodextrin (RMbetaCD) demonstrated the highest efficiency in solubilizing betaLAP.
  • Both freeze-drying and kneading methods successfully formed inclusion complexes, significantly improving betaLAP's dissolution efficiency compared to the pure drug or physical mixture.
  • The kneading method yielded a highly crystalline material with a superior dissolution profile (DE(20-minute) = 88.22%) compared to freeze-drying (DE(20-minute) = 67.15%).
  • Pure betaLAP had a DE(20-minute) of 27.11%, and the physical mixture had a DE(20-minute) of 27.22%.

Conclusions:

  • RMbetaCD is highly effective for forming inclusion complexes with betaLAP, significantly enhancing its dissolution.
  • The kneading method is the preferred technique for preparing RMbetaCD/betaLAP inclusion complexes due to its ability to produce a crystalline product with excellent dissolution characteristics.
  • The developed RMbetaCD/betaLAP inclusion complexes show promise for various therapeutic applications of betaLAP.