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Updated: Jul 11, 2026
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Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain
Published on: February 12, 2016
Interleukin-6 174G/C polymorphism and ischemic stroke: a systematic review
Amy R Tso1, José G Merino, Steven Warach
1National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Dr, Rm B1D733, MSC 1063, Bethesda, MD 20892, USA.
Stroke
|October 6, 2007
Summary
The interleukin-6 (IL-6) -174G/C polymorphism
Area of Science:
- Genetics and Molecular Biology
- Neuroscience
- Cardiovascular Disease
Background:
- Interleukin-6 (IL-6) plays a role in atherosclerosis and inflammatory responses to cerebral ischemia.
- The IL-6 -174G/C promoter polymorphism is linked to carotid artery and coronary heart disease.
- Its association with ischemic stroke remains unclear.
Purpose of the Study:
- To review existing literature on the IL-6 -174G/C polymorphism and ischemic stroke.
- To discuss methodological considerations for future research.
Main Methods:
- Searched PubMed MEDLINE, Scopus, and ISI Web of Science.
- Two independent reviewers identified studies on the IL-6 -174G/C polymorphism and ischemic cerebrovascular events.
Main Results:
- Nine independent studies were identified.
- Conflicting results were reported regarding the association between the IL-6 -174G/C polymorphism and ischemic stroke.
- Some studies found associations with the G allele or C allele, while others found no association.
Conclusions:
- Published results on the IL-6 -174G/C polymorphism and stroke are conflicting.
- Methodological limitations hinder interpretation.
- Future studies require greater rigor and consistency to clarify the relationship.
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