Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Endothelial precursor cells.

May J Reed1, Nathan Karres, Daniel Eyman

  • 1Department of Medicine, University of Washington, Harborview Medical Center, 300 Ninth Avenue, Seattle, WA, USA. mjr@u.washington.edu

Stem Cell Reviews
|October 6, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lecanemab alters basement membrane collagen IV in viable microvessels isolated from brains with high Alzheimer's disease neuropathology.

Journal of Alzheimer's disease : JAD·2026
Same author

Comparative permeability of the blood-brain barrier to albumin, DTPA, and sucrose: effects of inflammation-induced disruption.

Fluids and barriers of the CNS·2025
Same author

Transport of CCL2 across an induced pluripotent stem cell-derived in vitro model of the human blood-brain barrier is heparan sulfate-dependent.

PloS one·2025
Same author

Communication Surrounding Treatment Preferences for Older Adults With Dementia During Emergency Medical Services Response.

Journal of the American Geriatrics Society·2025
Same author

Prospective evaluation of comprehensive geriatric assessments in multidisciplinary bladder cancer care and implications for personalized vulnerability phenotyping.

Urologic oncology·2025
Same author

Test of Rapamycin in Aging Dogs (TRIAD): study design and rationale for a prospective, parallel-group, double-masked, randomized, placebo-controlled, multicenter trial of rapamycin in healthy middle-aged dogs from the Dog Aging Project.

GeroScience·2025
Same journal

Porcine embryonic stem cells: a possible source for cell replacement therapy.

Stem cell reviews·2008
Same journal

Paving the axonal highway: from stem cells to myelin repair.

Stem cell reviews·2008
Same journal

Epidermal neural crest stem cells (EPI-NCSC) and pluripotency.

Stem cell reviews·2008
Same journal

Role of gap junctions in embryonic and somatic stem cells.

Stem cell reviews·2008
Same journal

Esophageal stem cells--a review of their identification and characterization.

Stem cell reviews·2008
Same journal

Cord blood stem cells: a review of potential neurological applications.

Stem cell reviews·2008
See all related articles

Endothelial precursor cells (EPCs) show promise for older adults, but aging affects their function. This review explores EPCs in aging, angiogenesis, and cardiovascular disease for clinical applications.

Area of Science:

  • Gerontology
  • Cardiovascular Biology
  • Cell Biology

Background:

  • Endothelial precursor cells (EPCs) are crucial for blood vessel formation and repair.
  • Their potential therapeutic applications in older individuals are of significant interest.
  • Understanding EPCs is vital for addressing age-related cardiovascular decline.

Purpose of the Study:

  • To review the role of EPCs in angiogenesis and cardiovascular disease.
  • To examine how aging impacts EPC availability and function.
  • To define the clinical utility of EPCs in the older population.

Main Methods:

  • Literature review of studies on EPCs, aging, angiogenesis, and cardiovascular disease.
  • Analysis of existing data on age-related changes in EPC characteristics.

Related Experiment Videos

  • Synthesis of information regarding the clinical implications for older persons.

    • Main Results:

    • EPCs play a key role in maintaining vascular health.
    • Aging is associated with altered EPC numbers and impaired function.
    • These changes may limit the effectiveness of EPC-based therapies in older adults.

    Conclusions:

    • EPCs are important for vascular health, but their function declines with age.
    • Further research is needed to optimize EPC-based strategies for older individuals.
    • Understanding age-related EPC alterations is critical for future clinical applications in gerontology and cardiology.