Related Experiment Video
Updated: Jul 11, 2026

Direct Detection of the Acetate-forming Activity of the Enzyme Acetate Kinase
Published on: December 19, 2011
N-acetyl-L-tyrosine methyl ester monohydrate at 293 and 123 K
Alicja Janik1, Anna Chyra, Katarzyna Stadnicka
1Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Krakow, Poland. janik@chemia.uj.edu.pl
Abstract:
The crystal structure of a protected L-tyrosine, namely N-acetyl-L-tyrosine methyl ester monohydrate, C(12)H(15)NO(4).H(2)O, was determined at both 293 (2) and 123 (2) K. The structure exhibits a network of O-H...O and N-H...O hydrogen bonds, in which the water molecule plays a crucial role as an acceptor of one and a donor of two hydrogen bonds. Molecules of water and of the protected L-tyrosine form hydrogen-bonded layers perpendicular to [001]. C-H...pi interactions are observed in the hydrophobic regions of the structure. The structure is similar to that of N-acetyl-L-tyrosine ethyl ester monohydrate [Soriano-García (1993). Acta Cryst. C49, 96-97].
Related Concept Videos
Alkylation of β-Ketoester Enolates: Acetoacetic Ester Synthesis
Phase II Reactions: Acetylation Reactions
The substrates for acetylation are typically drugs or their metabolites with an amino, sulfonamide, or hydrazine functional group. Acetylation can occur at several points in the drug molecule, including primary, secondary, and...

