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Published on: December 1, 2020
Target deconvolution strategies in drug discovery.
Georg C Terstappen1, Christina Schlüpen, Roberto Raggiaschi
1Siena Biotech S.p.A., Via Fiorentina 1, 53100 Siena, Italy. gterstappen@sienabiotech.com
Nature Reviews. Drug Discovery
|October 6, 2007
Summary
Target deconvolution identifies molecular targets from observed phenotypic changes in complex biological systems. This review covers experimental strategies crucial for advancing drug discovery and development.
Area of Science:
- Pharmacology and Drug Discovery
- Systems Biology
- Chemical Biology
Background:
- Target-based drug discovery has limitations.
- A holistic approach using phenotypic screening is reviving.
- Understanding molecular targets is key for drug development.
Purpose of the Study:
- To critically review experimental strategies for target deconvolution.
- To highlight the importance of target identification in phenotypic drug discovery.
Main Methods:
- Review of diverse experimental strategies for target deconvolution.
- Analysis of approaches for identifying molecular targets from phenotypic data.
Main Results:
- Comprehensive overview of current target deconvolution methodologies.
- Identification of key experimental techniques applicable to complex biological systems.
Conclusions:
- Target deconvolution is essential for modern drug discovery.
- Effective strategies are available to identify molecular targets underlying phenotypic responses.
- Advancements in target deconvolution will accelerate drug development.
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