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[Protective effect of Sankang Capsule on immunity-deficiency mice induced by cyclophosphamide]
Xu Zhang1, Ru-Xue Zhang, Hong-Hai Tu
1Pharmaceutical College, Lanzhou University, Lanzhou 730000, China. zhangxucq@126.com
Objective:
To study the immunomodulatory effect of Sankang Capsule( SKC) on the immunity-deficiency mice.
Methods:
The immunity-deficiency model was induced by intraperitoneal injection (ip) of cyclophosphamide (CTX) at the dose of 100 mg/ kg in mice which were randomly divided into normal control group, immunity-deficiency model group, SKC treated group (250 mg/kg, 500 mg/kg) and positive control group (500 mg/kg). The number of WBC in peripheral blood, the weight of immune organs, the phagocytosis activity of macrophage, the content of serum hemolysin and the proliferation of T lymphocyte in the spleen were measured.
Results:
The number of WBC, the weight of immune organs, the phagocytosis activity of macrophage, the content of serum hemolysin and the proliferation of T lymphocyte in the model group were all decreased compared with those of normal control group. After the administration of SKC, the index mentioned above was increased compared with those of model group.
Conclusion:
SKC has a protective effect on the immunity-deficiency mice, which may be related to the increasing of cellular immunity, humoral immunity and nonspecific immunity.