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Related Experiment Videos

Competition between functional brain networks mediates behavioral variability.

A M Clare Kelly1, Lucina Q Uddin, Bharat B Biswal

  • 1The Phyllis Green and Randolph Cōwen Institute for Pediatric Neuroscience, NYU Child Study Center, New York, NY 10016, USA.

Neuroimage
|October 9, 2007
PubMed
Summary
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Individuals with attention disorders often show increased intraindividual variability. Stronger negative correlation between brain networks means more consistent performance, suggesting a key neural mechanism for attention regulation.

Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Psychiatry

Background:

  • Increased intraindividual variability (IIV) is characteristic of attention disorders.
  • Abnormalities in the default mode network (DMN) are linked to attention deficits.
  • A competitive relationship between the DMN and task-positive networks may underlie IIV.

Purpose of the Study:

  • To investigate the neural basis of attentional lapses and IIV.
  • To quantify the negative correlation between the DMN and task-positive networks.
  • To determine if this correlation predicts behavioral consistency.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) was used.
  • Resting-state and task-based (Eriksen flanker task) scans were performed.

Related Experiment Videos

  • The negative correlation between DMN and task-positive network activity was measured in 26 subjects.

    • Main Results:

    • The strength of the negative correlation between the two networks varied significantly across individuals.
    • Stronger negative correlation was associated with less variable behavioral performance (response times).
    • This relationship was consistent across resting and task conditions.

    Conclusions:

    • Individual differences in functional brain network integrity are behaviorally relevant.
    • The negative correlation between DMN and task-positive networks may serve as an index of attention regulation.
    • Findings shed light on the significance of spontaneous brain activity in attention and related disorders.