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Updated: Jul 11, 2026

Quantitation of Intra-peritoneal Ovarian Cancer Metastasis
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Stage I ovarian carcinoma: different clinical pathologic patterns.

Liane Deligdisch1, Frédérique Pénault-Llorca, Peter Schlosshauer

  • 1The Mount Sinai School of Medicine, Department of Pathology, New York, NY 10029, USA.

Fertility and Sterility
|October 9, 2007
PubMed
Summary

Most early-stage ovarian cancers are nonserous and present with symptoms like pelvic pain or bleeding. Serous papillary ovarian carcinoma is often asymptomatic, highlighting different patterns in early disease.

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Area of Science:

  • Gynecologic Oncology
  • Pathology
  • Clinical Medicine

Background:

  • Early-stage ovarian carcinoma exhibits diverse clinicopathologic presentations.
  • Understanding these patterns is crucial for timely diagnosis and management.
  • Distinguishing early-stage subtypes aids in predicting prognosis and treatment strategies.

Purpose of the Study:

  • To analyze the clinicopathologic patterns of early-stage ovarian carcinoma.
  • To identify differences in presentation between serous papillary and nonserous subtypes.
  • To correlate histopathology with clinical symptoms and associated conditions.

Main Methods:

  • Retrospective review of 76 consecutive Fédération Internationale de Gynécologie et d'Obstétrique stage I ovarian carcinoma cases.

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Last Updated: Jul 11, 2026

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Heterogeneity Mapping of Protein Expression in Tumors using Quantitative Immunofluorescence
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  • Analysis of surgical staging, symptomatology, pathology, and histology.
  • Chart and histopathology review conducted at Mount Sinai School of Medicine and Centre Jean Perrin.

    • Main Results:

    • Nonserous carcinomas constituted 71% of cases (endometrioid, clear cell, mixed types).
    • Serous papillary carcinomas (29%) were often asymptomatic, presenting as pelvic masses.
    • Nonserous carcinomas were frequently associated with endometriosis, endometrial carcinoma, polyps, or hyperplasia, presenting with pain or bleeding.

    Conclusions:

    • Over two-thirds of stage I ovarian carcinomas are nonserous and diagnosed due to symptoms like pelvic pain or vaginal bleeding.
    • Serous papillary carcinomas are often asymptomatic and detected incidentally.
    • Clinical evaluation of patients with endometriosis or breast cancer history should consider the risk of ovarian and endometrial malignancy.