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Plasma concentrations of urea and creatinine in primary school children in Ujung Pandang

G H Hamma1, S Rauf, D Daud

  • 1Child Health Department Medical Faculty, Hasanuddin University, Ujung Pandang.

Paediatrica Indonesiana
|July 1, 1991
PubMed

Insights

Plasma urea levels in children were unaffected by age or sex. However, creatinine levels were higher in well-nourished children and correlated with age, suggesting age-specific normal ranges for creatinine.

Area of Science:

  • Pediatric Nephrology
  • Clinical Biochemistry
  • Nutritional Science

Background:

  • Establishing reference ranges for plasma urea and creatinine is crucial for diagnosing kidney function in children.
  • Nutritional status can influence biochemical markers in pediatric populations.

Purpose of the Study:

  • To determine normal plasma urea and creatinine concentrations in primary school children.
  • To investigate the influence of sex, age, and nutritional status on these parameters.
  • To explore correlations between plasma urea and creatinine levels.

Main Methods:

  • A cross-sectional study involving 202 primary school children aged 6-15 years.
  • Multi-stage random sampling was employed for participant selection.
  • Plasma urea and creatinine concentrations were measured and analyzed.

Main Results:

  • Plasma urea concentrations showed no significant variation with sex, age, or nutritional status.
  • Plasma creatinine concentrations were significantly higher in well-nourished children compared to those with Protein-Energy Malnutrition (PEM).
  • A positive correlation was observed between age and plasma creatinine levels in both well-nourished and PEM groups.

Conclusions:

  • Normal plasma urea ranges are consistent across different sexes, ages, and nutritional statuses in this pediatric cohort.
  • Age-specific reference values for plasma creatinine are recommended due to its correlation with age and nutritional status.
  • No correlation was found between plasma urea and creatinine concentrations in the studied children.

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