Related Experiment Video
Updated: Jul 11, 2026

Rodent Model of Intestinal Ischemia-Reperfusion Injury via Occlusion of the Superior Mesenteric Artery
Published on: October 20, 2023
Acute stress-related gastrointestinal ischemia
R P Veenstra1, R H Geelkerken, P M Verhorst
1Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands. r.veenstra@erasmusmc.nl
Abstract:
We report a case of acute gastrointestinal ischemia during a very stressful event in whom the diagnosis was made by 24-hour tonometry. This case report unequivocally links a stressful event with increased catecholamine release and subsequent severe symptomatic gastrointestinal ischemia. The role of ischemia as potential pathophysiological mechanism has never been studied in detail. The clinical significance of finding such an association is underscored by this case report, where a vasoactive drug normally used for hypertension treatment resulted in greatly improved abdominal symptoms.
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