Simple machine-assisted protocol for solid-phase synthesis of depsipeptides
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Published on: May 15, 2012
Jan Spengler1, Beate Koksch, Fernando Albericio
1Institute for Research in Biomedicine, Barcelona Science Park, University of Barcelona, E-08028 Barcelona, Spain. jspengler@pcb.ub.es
Abstract:
A straightforward machine-assisted protocol for the synthesis of linear depsipeptides is reported. The synthesis was performed on a 433A Peptide Synthesizer (Applied Biosystems) using preprogrammed and optimized modules for Boc chemistry and without any need for hardware modification. The robustness of the protocol was demonstrated with 12 examples of 26-membered depsipeptides with single and multiple (up to 6) ester backbone substitutions.
