Related Experiment Videos
Hyperuricemia and gout: new insights into pathogenesis and treatment
Michael H Pillinger1, Pamela Rosenthal, Aryeh M Abeles
1New York University School of Medicine and Division of Rheumatology, NYU Hospital for Joint Diseases, New York, NY 10003, USA. michael.pillinger@med.nyu.edu
Abstract:
Over the past decade, significant advances have been made regarding the pathogenesis, clinical implications, and treatment of hyperuricemia. While physicians have understood for at least a century that uric acid causes gout, we are now beginning to address the question of why hyperuricemia exists and the mechanisms by which uric acid acts to stimulate inflammation. This review focuses on (1) previously unknown biological roles of uric acid; (2) why the loss of the uricase gene and resultant hyperuricemia may have provided an evolutionary advantage to primates and, in particular, to humans; (3) the molecular effects of uric acid on inflammatory cells; and (4) novel antihyperuricemic agents currently under study.
Related Concept Videos
Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
Urinary Tract Calculi IV: Nutrition Therapy and Prevention
Urinary Tract Calculi III: Medical Management
Acute Pyelonephritis II: Diagnostic Studies and Management
Urinary Tract Infection II: Pathophysiology
Acute Pancreatitis II: Clinical Manifestations and Management