Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Kinematic Equations: Problem Solving01:15

Kinematic Equations: Problem Solving

When analyzing one-dimensional motion with constant acceleration, the problem-solving strategy involves identifying the known quantities and choosing the appropriate kinematic equations to solve for the unknowns. Either one or two kinematic equations are needed to solve for the unknowns, depending on the known and unknown quantities. Generally, the number of equations required is the same as the number of unknown quantities in the given example. Two-body pursuit problems always require two...
Kinetic Energy for a Rigid Body01:13

Kinetic Energy for a Rigid Body

Imagine a solid object involved in a general planar movement, with its center of mass pinpointed at a spot labeled G. The object's kinetic energy relative to an arbitrary point A can be quantified for each of its particles - the ith particle in this case. This measurement is achieved through the employment of the relative velocity definition. The position vector, known as rA, extends from point A to the mass element i.
Kinematic Equations - I01:26

Kinematic Equations - I

When an object moves with constant acceleration, the velocity of the object changes at a constant rate throughout the motion. The kinematic equations of motions are derived for such cases where the acceleration of the object is constant. The first kinematic equation gives an insight into the relationship between velocity, acceleration, and time. We can see, for example:
Kinematic Equations - II01:17

Kinematic Equations - II

The second kinematic equation expresses the final position of an object in terms of its initial position, the distance traveled with the initial constant velocity, and the distance traveled due to a change in velocity. Similar to the first kinematic equation, this equation is also only valid when the acceleration is constant throughout the motion of an object.
Suppose a car merges into freeway traffic on a 200 m long ramp. If its initial velocity is 10 m/s and it accelerates at 2 m/s2, then the...
Kinematic Equations - III01:18

Kinematic Equations - III

The first two kinematic equations have time as a variable, but the third kinematic equation is independent of time. This equation expresses final velocity as a function of the acceleration and distance over which it acts. The fourth kinematic equation does not have an acceleration term and provides the final position of the object at time t in terms of the initial and final velocities. This equation is useful when the value of the constant acceleration is unknown.
Using the kinematic equations,...
Virtual Work for a System of Connected Rigid Bodies01:06

Virtual Work for a System of Connected Rigid Bodies

Virtual work is a powerful method used to solve problems involving several connected rigid bodies. When the system is in equilibrium, virtual work is zero. This allows the calculation of the resulting forces when a system undergoes a virtual displacement. When attempting to analyze such a system, first, use a free-body diagram, where an independent coordinate represents the configuration of the links, and mark its deflected position resulting from the positive virtual displacement.
Next,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bioinformatic assessment of the potential amyloidogenicity of the human and evolutionarily more ancient proteomes.

The Biochemical journalยท2026
Same author

Rapid antimicrobial susceptibility testing in bloodstream infections: current landscape and emerging technologies.

The Analystยท2026
Same author

Surface cues shape procoagulant properties of amyloidogenic microclots.

Cell death & diseaseยท2026
Same author

Why Standard Tests Miss Spike-Induced Clot Alterations.

Blood advancesยท2026
Same author

Assessing the Health and Functionality of the Microcirculation Using Thermal Imaging.

Journal of biophotonicsยท2026
Same author

How far can you go? Extrapolating values of catalytic activity from known protein landscapes in natural and directed evolution.

Chemical Society reviewsยท2026

Related Experiment Video

Updated: Jul 11, 2026

Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion
09:32

Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion

Published on: April 11, 2018

Something from nothing: bridging the gap between constraint-based and kinetic modelling.

Kieran Smallbone1, Evangelos Simeonidis, David S Broomhead

  • 1Manchester Centre for Integrative Systems Biology, The University of Manchester, UK. kieran.smallbone@manchester.ac.uk

The FEBS Journal
|October 10, 2007
PubMed
Summary

This study presents a novel method for creating kinetic models of metabolic networks using only reaction stoichiometry. This approach accurately predicts metabolic behavior without needing experimental kinetic data.

More Related Videos

Kinematic History of a Salient-recess Junction Explored through a Combined Approach of Field Data and Analog Sandbox Modeling
06:55

Kinematic History of a Salient-recess Junction Explored through a Combined Approach of Field Data and Analog Sandbox Modeling

Published on: August 5, 2016

Related Experiment Videos

Last Updated: Jul 11, 2026

Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion
09:32

Subject-specific Musculoskeletal Model for Studying Bone Strain During Dynamic Motion

Published on: April 11, 2018

Kinematic History of a Salient-recess Junction Explored through a Combined Approach of Field Data and Analog Sandbox Modeling
06:55

Kinematic History of a Salient-recess Junction Explored through a Combined Approach of Field Data and Analog Sandbox Modeling

Published on: August 5, 2016

Area of Science:

  • Systems Biology
  • Metabolic Engineering
  • Computational Biology

Background:

  • Metabolic modeling aids understanding of cellular metabolism and regulation.
  • Constraint-based modeling offers quantitative insights with minimal data but lacks substrate concentration details.
  • Kinetic modeling provides mechanistic detail but is data-intensive and time-consuming.

Purpose of the Study:

  • To develop a method for constructing kinetic models of metabolic networks using solely reaction stoichiometry.
  • To overcome the data requirements and limitations of traditional kinetic modeling approaches.
  • To enable dynamic analysis of metabolic networks without experimental kinetic constants.

Main Methods:

  • Utilized reaction stoichiometries to build a kinetic model.
  • Employed flux balance analysis (FBA) to estimate system fluxes.
  • Integrated linlog kinetics for dynamic flux variation and estimated elasticities from stoichiometry.

Main Results:

  • Developed a kinetic model based purely on stoichiometric information.
  • Achieved excellent agreement with a yeast glycolysis model without experimental kinetic data.
  • Demonstrated the ability to derive analytical forms for steady-state determination, stability analysis, and dynamical behavior studies.

Conclusions:

  • The proposed method successfully generates accurate kinetic metabolic models from stoichiometric data alone.
  • This approach significantly reduces the experimental burden associated with kinetic model development.
  • The methodology provides a powerful tool for analyzing metabolic network dynamics and regulation.