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Related Experiment Videos

The aging gut: physiology.

John E Morley1

  • 1Division of Geriatric Medicine, Saint Louis University Medical Center, Saint Louis University School of Medicine, 1402 South Grand Boulevard, M238, St. Louis, MO 63104, USA. morley@slu.edu

Clinics in Geriatric Medicine
|October 10, 2007
PubMed
Summary
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Aging affects the gastrointestinal tract subtly, influencing conditions like anorexia, hypotension, and infections. These physiological shifts impact digestion, nutrient absorption, and medication efficacy in older adults.

Area of Science:

  • Gerontology
  • Gastroenterology
  • Physiology

Background:

  • Physiological changes in the gastrointestinal tract (GIT) with aging are often less apparent than in other organ systems.
  • Despite being subtle, these changes significantly contribute to various age-related health issues.

Purpose of the Study:

  • To elucidate the role of physiological changes in the aging gastrointestinal tract.
  • To connect these changes to specific clinical manifestations in the elderly.

Main Methods:

  • Review of existing literature on gastrointestinal physiology and aging.
  • Analysis of clinical data linking age-related GIT changes to health outcomes.

Main Results:

  • Age-related gastrointestinal changes contribute to anorexia of aging and postprandial hypotension.

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  • These physiological shifts increase susceptibility to aspiration pneumonia and Clostridium difficile infections.
  • Altered gastrointestinal function impacts drug metabolism and increases gallstone formation.

    • Conclusions:

    • Subtle physiological alterations in the aging gastrointestinal tract have profound clinical implications.
    • Understanding these changes is crucial for managing common geriatric conditions and optimizing pharmacotherapy.