Related Experiment Video
Updated: Jul 11, 2026

A Preclinical Model of Exertional Heat Stroke in Mice
Published on: July 1, 2021
Identification of risk factors for exertional heat illness: a brief commentary on genetic testing
Sheila Muldoon1, Rolf Bunger, Patricia Deuster
1Department of Anesthesiology, Uniformed Services University, Bethesda, MD, USA. smuldoon@usuhs.mil
Objective:
This commentary discusses known links between Exertional Heat Illness (EHI), Malignant Hyperthermia (MH), and other hereditary diseases of muscle. Genetic and functional testing is also evaluated as measures of fitness to return to duty/play.
Data Sources:
Reviews and research articles from Sports Medicine, Applied Physiology, and Anesthesiology.
Data Extraction:
Detailed comparisons of existing literature regarding clinical cases of EHI and MH and the potential utility of genetic testing, specifically the ryanodine receptor (RYR1) gene and other genes related to disorders of skeletal muscle.
Data Synthesis:
EHI is a complex disorder wherein physiological, environmental, and hereditary factors interact to endanger an individual's ability to maintain thermal homeostasis.
Conclusions:
Individuals' genetic background is likely to play an important role, particularly when EHI recurs. Recurrent EHI has been associated with MH and other genetic disorders, highlighting the importance of identification and exclusion of individuals with known high risk factors.
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