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Related Experiment Videos

Maintaining immunological tolerance with Foxp3.

Lauren E Mays1, Youhai H Chen

  • 1Department of Pathology and Laboratory Medicine, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. maysle@mail.med.upenn.edu

Cell Research
|October 10, 2007
PubMed
Summary
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Regulatory T cells (Tregs) are crucial for preventing autoimmunity by controlling self-reactive T cells. This study explores the critical role of the transcription factor Foxp3 in Treg development and function, defining its transcriptional program.

Area of Science:

  • Immunology
  • Molecular Biology
  • Genetics

Background:

  • Central tolerance in the thymus aims to eliminate autoreactive T cells but is imperfect.
  • Self-reactive T cells escaping thymic deletion pose a risk for autoimmunity.
  • Naturally occurring regulatory T cells (Tregs) are essential for controlling autoreactivity.

Purpose of the Study:

  • To define the largely undefined transcriptional program driven by Foxp3.
  • To elucidate the role of Foxp3 in the development and function of regulatory T cells.
  • To discuss the discovery, phenotype, development, maintenance, and function of naturally occurring Tregs.

Main Methods:

  • Genome-wide characterization of target genes bound and regulated by Foxp3.
  • Analysis of Foxp3's cooperation with other transcription factors like NFAT.

Related Experiment Videos

Main Results:

  • Foxp3 is crucial for thymic development and peripheral function of Tregs.
  • Foxp3 cooperates with transcription factors such as NFAT.
  • Directly bound and regulated target genes of Foxp3 have been characterized genome-wide.

Conclusions:

  • Naturally occurring regulatory T cells, defined by Foxp3, are vital for immune homeostasis.
  • Understanding Foxp3's transcriptional program is key to understanding Treg function.
  • Foxp3 plays a critical role in preventing autoimmunity through Treg-mediated suppression.