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Updated: Jul 11, 2026
09:16
FIBS-enabled Noninvasive Metabolic Profiling
Published on: February 3, 2014
Metabolic fingerprinting as a diagnostic tool
David I Ellis1, Warwick B Dunn, Julian L Griffin
1University of Manchester, School of Chemistry, Manchester Interdisciplinary Biocentre, 131 Princess Street, Manchester M1 7ND, UK. D.Ellis@manchester.ac.uk
Pharmacogenomics
|October 11, 2007
Summary
Metabolomics, particularly metabolic fingerprinting, offers unique advantages for disease diagnostics. This review covers key techniques like spectroscopy and mass spectrometry for identifying diseases.
Area of Science:
- Systems biology
- Omics technologies (genomics, transcriptomics, proteomics, metabolomics, lipidomics)
Background:
- Intense activity in functional analyses across 'omic levels in the early 21st century.
- Metabolomics presents unique advantages over other 'omics disciplines.
- Metabolic fingerprinting is a core metabolomics approach for disease diagnostics.
Purpose of the Study:
- To provide an overview of metabolic fingerprinting approaches for disease diagnostics.
- To highlight established and emerging techniques in the field.
Main Methods:
- Infrared and Raman spectroscopy.
- Nuclear Magnetic Resonance (NMR) spectroscopy.
- Mass spectrometry-based methods (novel and under development).
Main Results:
- The review consolidates information on various metabolic fingerprinting techniques.
- It identifies key spectroscopic and mass spectrometry methods relevant to diagnostics.
Conclusions:
- Metabolic fingerprinting is a powerful tool for disease diagnostics.
- The review serves as a resource for researchers and clinicians exploring multidisciplinary diagnostic approaches.
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