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Related Concept Videos

Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...

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Related Experiment Video

Updated: Jul 11, 2026

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
07:17

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation

Published on: April 14, 2016

Cancer-associated bone disease.

Sue A Brown1, Theresa A Guise

  • 1Department of Medicine, University of Virginia,P.O. Box 801420, Charlottesville, VA 22908, USA. sab2f@virginia.edu

Current Osteoporosis Reports
|October 11, 2007
PubMed
Summary

Cancer patients face skeletal risks like bone loss and metastases from treatments. Early screening and therapies, including bisphosphonates, can mitigate these bone complications.

Area of Science:

  • Oncology
  • Endocrinology
  • Orthopedics

Background:

  • Cancer patients are susceptible to skeletal complications, including bone metastases and treatment-induced bone loss.
  • Therapies such as hormonal therapy, chemotherapy, and glucocorticoids can negatively impact bone health.
  • Common cancers associated with skeletal issues include breast cancer, prostate cancer, and multiple myeloma.

Purpose of the Study:

  • To review risk factors and mechanisms of cancer-related bone loss and metastases.
  • To discuss strategies for detecting bone complications in cancer patients.
  • To outline therapeutic approaches for managing skeletal-related events in oncology.

Main Methods:

  • Literature review of risk factors, mechanisms, and management strategies for skeletal complications in cancer.

More Related Videos

Models of Bone Metastasis
08:49

Models of Bone Metastasis

Published on: September 4, 2012

Related Experiment Videos

Last Updated: Jul 11, 2026

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation
07:17

Murine Hind Limb Long Bone Dissection and Bone Marrow Isolation

Published on: April 14, 2016

Models of Bone Metastasis
08:49

Models of Bone Metastasis

Published on: September 4, 2012

  • Focus on common cancers: breast cancer, prostate cancer, and multiple myeloma.
  • Analysis of screening, lifestyle modifications, and anti-osteoporosis therapies.

    • Main Results:

    • Cancer therapies significantly increase the risk of bone loss and fractures.
    • Metastatic bone disease presents a major challenge in cancer care.
    • Early detection and intervention are crucial for managing skeletal-related events.

    Conclusions:

    • Proactive screening for bone loss and timely initiation of anti-osteoporosis treatments are essential.
    • Management strategies should address both cancer treatment side effects and bone metastases.
    • Multidisciplinary care is vital for optimizing skeletal health in cancer patients.