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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Acne Infection01:27

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
Pleiotropy01:33

Pleiotropy

Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Pigmentation01:19

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...

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Related Experiment Video

Updated: Jul 11, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
06:15

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

[Nevus comedonicus syndrome].

N El Ghelbazouri1, N Ismaili, N Ahrich

  • 1Service de Dermatologie, CHU Ibn Sina, Rabat, Maroc. najlaa39@caramail.com

Annales De Dermatologie Et De Venereologie
|October 11, 2007
PubMed
Summary
This summary is machine-generated.

Nevus comedonicus, a rare skin condition, presented with extensive lesions on one side of a patient

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Area of Science:

  • Dermatology
  • Medical Genetics

Background:

  • Nevus comedonicus is a rare congenital skin disorder.
  • It can occur in isolation or as part of nevus comedonicus syndrome, involving other congenital malformations.

Observation:

  • A 20-year-old woman presented with widespread, congenital cribriform plaques and comedonic lesions.
  • Lesions affected the face, left hemithorax, and left upper limb, with a distinct midline demarcation.
  • The patient had a history of congenital cataract in the left eye.

Findings:

  • Histological examination confirmed the clinical diagnosis of nevus comedonicus.
  • The extensive unilateral presentation and association with congenital cataract suggest nevus comedonicus syndrome.
  • No other extracutaneous abnormalities were detected through laboratory screening.

Implications:

  • This case highlights the rare presentation of nevus comedonicus syndrome.
  • It underscores the importance of considering extracutaneous associations, particularly ocular, in extensive nevus comedonicus cases.
  • Early recognition of nevus comedonicus syndrome is crucial for managing associated congenital malformations.