Related Experiment Video
Updated: Jul 11, 2026
09:45
Histological Quantification of Chronic Myocardial Infarct in Rats
Published on: December 11, 2016
[Myocardial morphology in cases of death from acute heart ischemic disease]
Arkhiv Patologii
|October 12, 2007
Insights
Sudden cardiac death from acute ischemic heart diseases shows subtle left ventricular wall thickening. Microscopic analysis reveals myocyte damage and altered tissue structure.
Area of Science:
- Cardiology
- Pathology
Context:
- Acute ischemic heart diseases, including acute coronary insufficiency and acute myocardial infarction, are leading causes of mortality.
- Understanding the cardiac structural changes post-mortem is crucial for accurate diagnosis and forensic analysis.
Purpose:
- To investigate the morphological changes in the left ventricular wall following death from acute ischemic heart diseases.
- To correlate macroscopic findings with microscopic pathological alterations.
Summary:
- Deaths from acute ischemic heart diseases (n=39 acute coronary insufficiency, n=36 acute myocardial infarction) exhibited a slight increase in left ventricular wall thickness.
- Microscopic examination revealed significant pathological changes including increased intermuscular distances, cardiomyocytic thickening, nuclear polymorphism, contractures, and myocyte destruction (lysis).
Impact:
- Provides detailed histopathological insights into the terminal phase of acute ischemic heart events.
- Contributes to the understanding of cardiac remodeling and cellular injury in fatal ischemic heart conditions.
Abstract:
The death from acute ischemic heart diseases (acute coronary insufficiency (n = 39) and acute myocardial infarction (n = 36) is accompanied by a slight increase in the thickness of the left ventricular wall with preserved normal heart weight. Microscopically, there are longer intermuscular distances, cardiomyocytic thickening, nuclear polymorphism, contractures, and destruction of myocytes and their lysis.
Related Concept Videos
01:21Myocarditis I: Introduction
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
01:27Myocarditis II: Clinical Features and Diagnostic Tests
Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
01:30Acute Coronary Syndrome III: Diagnostic Studies
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
01:30Acute Coronary Syndrome I: Introduction
Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
01:19Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
01:17Ischemic Heart Disease: Overview
Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and narrowing...
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and narrowing...