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Lactobacillus casei-induced polyarthritis in Lewis rats: histopathological scoring system for evaluation of
E M O'Byrne1, E D Roberts, A S Rubin
1CIBA-GEIGY Corporation, Research Department, Summit, NJ 07901.
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|September 1, 1991
Abstract:
A histopathological scoring system which grades drug effects on cellular infiltration, pannus formation, cartilage degradation and bone resorption in L. casei-induced polyarthritis in rats is described. Reference anti-rheumatic and anti-inflammatory agents administered on days 2-60 after induction of arthritis were evaluated for effects on paw swelling weekly and graded histopathologic changes on day 60. This animal model affords a tool to evaluated therapeutic agents on the joint destruction resulting from chronic inflammation.