Related Experiment Video
Updated: Jul 10, 2026

In Vitro Cellular Activity Evaluation of the Nanoemulsion Vaccine Adjuvant Ophiopogonin D
Published on: December 9, 2022
ISCOMATRIX adjuvant for prophylactic and therapeutic vaccines
Debbie Drane1, Charmaine Gittleson, Jeff Boyle
1CSL Limited, 45 Poplar Road, Parkville, 3052 Victoria, Australia. debbie.drane@csl.com.au
The ISCOMATRIX adjuvant enhances vaccine immune responses by improving antigen delivery and presentation. Clinical trials show ISCOMATRIX vaccines are safe and well-tolerated, generating broad antibody and T cell immunity.
Area of Science:
- Immunology and Vaccine Development
- Adjuvant Technology
Background:
- The ISCOMATRIX adjuvant possesses intrinsic antigen-delivery, antigen-presentation, and immunomodulatory properties.
- These combined capabilities are designed to elicit robust and rapid immune responses.
Purpose of the Study:
- To evaluate the safety, tolerability, and immunogenicity of ISCOMATRIX-based vaccines in clinical trials.
- To assess the breadth of immune responses, including antibody subclasses and T cell activation.
Main Methods:
- Evaluation of ISCOMATRIX adjuvant combined with various antigens in human clinical trials.
- Assessment of immune responses, including antibody titers, subclass analysis, and CD4+/CD8+ T cell responses.
Main Results:
- ISCOMATRIX vaccines demonstrated a favorable safety profile and were generally well tolerated across studies.
- Significant enhancement and acceleration of vaccine-induced immune responses were observed.
- Broad immune responses were induced, encompassing diverse antibody subclasses and both CD4+ and CD8+ T cell populations.
Conclusions:
- The ISCOMATRIX adjuvant is a safe and effective component for vaccine formulations.
- ISCOMATRIX adjuvant significantly boosts vaccine immunogenicity, leading to comprehensive immune protection.
More Related Videos
07:32Evaluating the Immune Response of a Nanoemulsion Adjuvant Vaccine Against Methicillin-Resistant Staphylococcus aureus (MRSA) Infection
Published on: September 1, 2023
13:36Utilizing the Antigen Capsid-Incorporation Strategy for the Development of Adenovirus Serotype 5-Vectored Vaccine Approaches
Published on: May 6, 2015
Related Concept Videos
Cancer Vaccines
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Vaccinations
Tumor Immunotherapy
Development of Immunocompetence
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Hypersensitivity Reactions: Immune-Complex Reactions
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...