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Progesterone binding in human endometrial carcinomas.

P C Young, C E Ehrlich, R E Cleary

    American Journal of Obstetrics and Gynecology
    |June 1, 1976
    PubMed
    Summary
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    Progesterone receptor levels decrease in endometrial cancer as it progresses. This study found reduced progesterone binding in endometrial carcinomas, polyps, and hyperplastic endometria compared to normal tissue.

    Area of Science:

    • Endocrinology
    • Gynecologic Oncology
    • Molecular Biology

    Background:

    • Progesterone receptors (PR) play a crucial role in normal endometrial function and are important therapeutic targets in endometrial cancer.
    • Understanding PR expression and binding capacity in various endometrial conditions is essential for diagnosis and treatment strategies.

    Purpose of the Study:

    • To quantify and compare the specific progesterone-binding capacity in cytosol preparations from normal endometria, endometrial polyps, hyperplastic endometria, endometrial adenocarcinomas of varying grades, and non-endometrial gynecologic tumors.
    • To investigate the relationship between progesterone receptor levels and clinicopathological features of endometrial adenocarcinoma, including tumor grade and patient age.

    Main Methods:

    • Dextran-coated charcoal assay was employed to measure the specific binding of 3H-progesterone in endometrial cytosol preparations.

    Related Experiment Videos

  • Progesterone-binding capacity was categorized as high or low based on an arbitrary cutoff of 50 femtomoles of bound 3H-progesterone per milligram of cytosol protein.

    • Main Results:

    • Normal endometria (19/20) and hyperplastic endometria (7/9) predominantly exhibited high progesterone-binding capacity.
    • Endometrial carcinomas showed a trend of decreasing progesterone-binding capacity with increasing tumor grade (Grade I: 2/11, Grade II: 3/8, Grade III: 2/4).
    • Endometrial polyps (4/4) and non-endometrial gynecologic tumors (0/7) also demonstrated high and low binding capacities, respectively. Irradiated tumors consistently showed low binding capacity. An inverse relationship between patient age and PR concentration in adenocarcinomas was observed.

    Conclusions:

    • A progressive loss of specific progesterone-binding activity occurs from normal to hyperplastic endometria and from well-differentiated to anaplastic endometrial adenocarcinomas.
    • Progesterone receptor status may serve as a biomarker for endometrial cancer progression and differentiation.
    • Age may influence progesterone receptor concentration in endometrial adenocarcinomas, warranting further investigation.