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Related Experiment Video

Updated: Jul 10, 2026

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
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Published on: May 14, 2013

Pimecrolimus and dual pimecrolimus-paclitaxel eluting stents decrease neointimal proliferation in a porcine model.

Ryan Berg1, Joseph Aragon, Vladimir Royter

  • 1Division of Cardiology, Cedars Sinai Medical Center, Los Angeles, California, USA. ryan.berg@cshs.org

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
|October 13, 2007
PubMed
Summary
This summary is machine-generated.

Pimecrolimus drug-eluting stents effectively reduced neointimal proliferation and inflammation in a porcine coronary model. A dual drug-eluting stent combining pimecrolimus and paclitaxel also demonstrated safety and efficacy.

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Area of Science:

  • Cardiovascular Research
  • Biomedical Engineering
  • Pharmacology

Background:

  • Coronary artery disease necessitates advanced treatment strategies.
  • Drug-eluting stents (DES) aim to prevent restenosis after percutaneous coronary intervention.
  • Evaluating novel DES formulations is crucial for improving patient outcomes.

Purpose of the Study:

  • To assess the efficacy of pimecrolimus-eluting stents (PES) and a combination stent (pimecrolimus + paclitaxel) in a porcine coronary model.
  • To compare the vascular response of these DES against bare metal stents (BMS).

Main Methods:

  • Phase 1: Cobalt chromium stents loaded with slow-release or fast-release pimecrolimus were implanted in pigs (n=10).
  • Phase 2: Stents with alternating reservoirs of paclitaxel and pimecrolimus were implanted in pigs (n=7).
  • Vascular response, including neointimal proliferation, inflammation, and endothelialization, was assessed at 30 days.

Main Results:

  • Fast-release PES significantly reduced neointimal proliferation and inflammation compared to BMS.
  • Dual drug-eluting stents (DDES) also showed significantly reduced neointimal proliferation versus BMS.
  • Complete endothelialization was observed in all stent groups, indicating arterial healing.

Conclusions:

  • Pimecrolimus effectively inhibits neointimal proliferation in a porcine coronary stent model.
  • The study established the proof of concept for a dual drug-eluting stent, demonstrating its safety and efficacy.