[Mechanisms of immunosuppression in surgical pathology]

The mechanisms of immunodeficiency in surgical pathology are described. They are consequences of stress, anesthesia, operation, endotoxinemia, blood loss. The duration of secondary immunodeficiency and prognosis depend on the degree of tissue traumatization, scope of operation, peculiarities of pathologic process and the state of host defence, its capacity for mobilization in extreme situation. Transient damages of the early postoperative "shock" period are most pronounced and form a "window" for immunodeficiency development and infections association in subsequent period. Hence it seems reasonable to conduct immunoprophylaxis in the preoperative period and immunocorrection after the operation this aiming at lower lethality in surgical pathology.