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Updated: Jul 10, 2026
08:38
Renal Capsule Xenografting and Subcutaneous Pellet Implantation for the Evaluation of Prostate Carcinogenesis and Benign Prostatic Hyperplasia
Published on: August 28, 2013
Prostate growth and inflammation.
Alessandro Sciarra1, Gianna Mariotti, Stefano Salciccia
1Department of Urology U Bracci, University La Sapienza, Via Nomentana 233, Rome, Italy. sciarrajr@hotmail.com
The Journal of Steroid Biochemistry and Molecular Biology
|October 16, 2007
Summary
Prostatic inflammation is linked to increased risk of benign prostatic hyperplasia (BPH) and prostate cancer (PC). Evidence suggests inflammation drives prostate growth and neoplastic changes, highlighting its significant role.
Area of Science:
- Urology
- Oncology
- Inflammation Research
Background:
- Emerging evidence links prostatic inflammation to prostate growth, including benign prostatic hyperplasia (BPH) and prostate cancer (PC).
- Inflammation is hypothesized to promote carcinogenesis through cellular and genomic damage, increasing cell turnover.
Purpose of the Study:
- To review clinical data supporting the role of inflammation in BPH and PC growth and progression.
- To synthesize personal experience and international literature on inflammation's impact on prostate health.
Main Methods:
- Literature review of clinical data on inflammation and prostate diseases.
- Analysis of personal experience and published studies on BPH and PC.
- Examination of evidence linking inflammation to prostate cancer development.
Main Results:
- 57% of patients with self-reported prostatitis had a history of BPH.
- Inflammation significantly increases the risk of BPH progression and acute urinary retention.
- Prostate inflammation, potentially linked to bacterial colonization, correlates with PC diagnosis and may precede cancer development (PIA).
Conclusions:
- The association between inflammation and prostate growth (BPH) and cancer risk (PC) is strongly suggested.
- Inflammation appears to be a significant factor in the pathogenesis of both benign and malignant prostate conditions.
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