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Updated: Jul 10, 2026

Spatio-Temporal In Vivo Imaging of Ocular Drug Delivery Systems using Fiberoptic Confocal Laser Microendoscopy
Published on: September 27, 2021
[Ocular fluorophores]
1Spitalul Clinic de Urgentă Militar Central, Bucureşti.
Abstract:
The majority of ocular media and tissues are lifelong exposed to electromagnetic radiations. O series of photochemical and photobiological events take place in these tissues and especially in the lens and the retina, thus resulting a permanent changing of their optical and functional qualities; the result of most of these events is the appearance of fluorescent molecular aggregates due to the alterations of initially non-fluorescent molecules or to accumulation processes (these are the endogenous fluorophores; their quantity and intraocular distribution is age- and light-exposure-linked and can be altered by pathology). Willingly or not, fluorescent substances can be introduced in the eye through its hematic barriers (these are the exogenous fluorophores).
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