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Published on: February 14, 2022
Comparative antianaerobic activities of doripenem determined by MIC and time-kill analysis
Kim L Credito1, Lois M Ednie, Peter C Appelbaum
1Department of Pathology, Hershey Medical Center, PO Box 850, Hershey, PA 17033, USA.
Antimicrobial Agents and Chemotherapy
|October 17, 2007
Abstract:
Against 447 anaerobe strains, the investigational carbapenem doripenem had an MIC 50 of 0.125 microg/ml and an MIC 90 of 1 microg/ml. Results were similar to those for imipenem, meropenem, and ertapenem. Time-kill studies showed that doripenem had very good bactericidal activity compared to other carbapenems, with 99.9% killing of 11 strains at 2x MIC after 48 h.
