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Related Experiment Video

Updated: Jul 10, 2026

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers

Published on: March 3, 2023

Hydroxyurea-induced leg ulcers treated with a protease-modulating matrix.

Marco Romanelli¹, Valentina Dini, Paolo Romanelli

¹Department of Dermatology, University of Pisa, Pisa, Italy. m.romanelli@med.unipi.it

Archives of Dermatology

|October 17, 2007

Summary

Hydroxyurea (HU) can cause painful leg ulcers in myeloproliferative disease patients. A novel dressing modulating matrix metalloproteinases offers a safe and effective treatment for these challenging wounds.

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Last Updated: Jul 10, 2026

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers

Prospective, Randomized, and Controlled Study of a Human Umbilical Cord Mesenchymal Stem Cell Injection for Treating Diabetic Foot Ulcers

Published on: March 3, 2023

Area of Science:

Dermatology
Wound Healing
Pharmacology

Background:

Hydroxyurea (HU) is used for myeloproliferative diseases.
Long-term, high-dose HU can rarely cause painful ankle leg ulcers.
Limited treatment options exist for these chronic wounds.

Observation:

Two patients with HU-induced leg ulcers were treated.
A freeze-dried sponge containing oxidized regenerated cellulose and collagen was used.
This dressing physically entraps and inhibits proteases like plasmin and matrix metalloproteinases.

Findings:

Successful wound healing was observed in both patients.
The dressing effectively modulated protease activity.
This treatment was safe and well-tolerated.

Implications:

Topical matrix metalloproteinase modulators are a viable treatment for HU-induced leg ulcers.
This approach offers a new therapeutic strategy for recalcitrant wounds.
Further research may validate this treatment for similar dermatological complications.