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Right ventricular assistance by continuous flow device. A numerical simulation.

C De Lazzari1, G Ferrari

  • 1C.N.R., Institute of Clinical Physiology-Rome Section-Italy, Group of Cardiovascular Engineering, V.le dell'Università, 11, 00185 Rome, Italy. dela@ifc.cnr.it

Methods of Information in Medicine
|October 17, 2007
PubMed
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This study simulated continuous flow assistance for right ventricular failure. Increasing pump speed significantly improved total blood flow and reduced right atrial pressure, aiding cardiac function.

Area of Science:

  • Cardiovascular physiology
  • Medical device simulation
  • Computational fluid dynamics

Background:

  • Continuous flow assistance is crucial for managing right ventricular failure.
  • Computer simulations offer a method to study the impact of such assistance on cardiac function.
  • The CARDIOSIM model provides a platform for simulating cardiovascular dynamics.

Purpose of the Study:

  • To evaluate the hemodynamic effects of continuous flow assistance on a failing right ventricle.
  • To assess the influence of varying right ventricular end-systolic elastance and pump speed on key circulatory variables.

Main Methods:

  • Incorporated a rotary blood pump model into the CARDIOSIM software.
  • Utilized lumped parameter models to represent circulatory phenomena and variable elastance models for ventricular function.

Related Experiment Videos

  • Investigated three distinct values for right ventricular end-systolic elastance (EmaxRIGHT) and pump rotational speed.

    • Main Results:

    • Pump speed significantly impacted right ventricular volumes, right atrial pressure (Pra), and flows (Qro).
    • Lower right ventricular end-systolic elastance amplified the effects on pulmonary arterial pressure (Pap).
    • Increased pump speed led to decreased mean Pra and increased total flow (Qro + pump flow).

    Conclusions:

    • Simulations indicate that Hemopump increases total cardiac output.
    • The device reduces the workload of the right ventricle by decreasing its native ejection.
    • Continuous flow assistance effectively lowers right atrial pressure in simulated right ventricular failure.