The association between current Helicobacter pylori infection and coronary artery disease
Seung-Won Jin1, Sung-Ho Her, Jong-Min Lee
1Department of Internal Medicine, The Catholic University of Korea College of Medicine, Seoul Korea.
Insights
Helicobacter pylori (H. pylori) infection shows a modest influence on coronary artery disease (CAD) and progressive atheroma. Further research is needed to fully understand the H. pylori and CAD relationship.
Area of Science:
- Cardiology
- Gastroenterology
- Infectious Diseases
Background:
- The association between Helicobacter pylori (H. pylori) infection and coronary artery disease (CAD) remains controversial.
- Previous studies have not fully examined the link between current H. pylori infection and CAD pathogenesis.
- This study investigates the relationship between H. pylori infection, confirmed via biopsy, and the presence of CAD.
Purpose of the Study:
- To evaluate the association between H. pylori infection and coronary artery disease (CAD).
- To determine if H. pylori infection influences the progression of atheroma in CAD patients.
Main Methods:
- Gastroduodenoscopic biopsy was used to detect H. pylori infection in 88 normal coronary angiogram patients and 175 CAD patients.
- Tissue samples were stained using Warthin-starry silver stain to identify H. pylori.
- Patients with a history of H. pylori eradication or malignancy were excluded.
Main Results:
- H. pylori infection was present in 30.7% of the control group and 40.6% of the CAD group, with no statistically significant difference.
- No significant difference in reintervention rates was observed between H. pylori positive and negative CAD patients undergoing percutaneous coronary intervention (PCI).
- Demographic and laboratory characteristics were similar between groups, except for gender, age, smoking, and HDL-c levels.
Conclusions:
- H. pylori infection appears to have a modest influence on CAD and progressive atheroma.
- A tendency for increased risk was observed, but not statistically significant.
- Further research is required to elucidate the complex relationship between H. pylori infection and CAD.
Background:
The role of Helicobacter pylori (H. pylori) in the pathogenesis of coronary artery disease (CAD) is still controversial, and the relation between current H. pylori infection and CAD has not been fully examined. This study evaluated the relation between H. pylori infection as confirmed by gastroduodenoscopic biopsy and CAD.
Methods:
We determined the presence of H. pylori infections, via gastroduodenoscopy, in 88 patients of the normal coronary angiographic group and also in 175 patients of the CAD group, and the latter patients had more than 50% coronary stenosis angiographically demonstrated. We excluded those patients with a history of previous H. pylori eradication and/or malignancy. A small piece of tissue from the antrum, which was obtained by gastroduodenoscopic biopsy, was stained by Warthin-starry silver stain. We defined a negative staining result that there was no stained tissue in the sample and the stained tissue was also positive for H. pylori infection.
Results:
There was no significant difference, except for gender, age, smoking and high density lipoprotein cholesterol (HDL-c), of the demographic and laboratory characteristics between the groups. Twenty seven (30.7%) patients of the normal control group and 71 (40.6%) patients of the CAD group were positive of H. pylori infection, yet there was no statistical difference. We angiographically followed up the 80 patients of the CAD group who were treated by percutaneous coronary intervention (PCI) at 6 to 9 months after their primary intervention. Twenty two (37.9%) of the 58 patients of the H. pylori negative group and 10 (45.5%) of the 22 patients of the H. pylori positive group were treated with reintervention, but reintervention was also not significantly different between the group with H. pylori infection and the group without the infection.
Conclusions:
These data indicated that H. pylori infection had a modest influence on CAD and progressive atheroma, but the showed a tendency to increase. Further studies are needed to evaluate the relationship between H. pylori infection and CAD.
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