Synthesis of phosphorothioate oligonucleotide-peptide conjugates by solid phase fragment condensation
Irmina Diala1, Akira Osada, Shinji Maruoka
1School of Humanity Oriented Science and Technology, Kinki University, 11-6 Kayanomori, Iizuka, Fukuoka 820-8555, Japan.
Bioorganic & Medicinal Chemistry Letters
|October 19, 2007
Abstract:
Phosphorothioate oligonucleotide-peptide conjugates were synthesized by solid phase fragment condensation (SPFC). Arginine rich peptides could be successfully conjugated in 2.8-13.4% isolated yields. All the products were fully characterized by reversed phase HPLC and MALDI-TOF-MS to give satisfactory results.
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