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The relationship between evolutionary and physiological variation in hemoglobin.

Ron Milo1, Jennifer H Hou, Michael Springer

  • 1Department of Systems Biology, Harvard Medical School, Boston, MA 02115, USA.

Proceedings of the National Academy of Sciences of the United States of America
|October 19, 2007
PubMed
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Physiological and evolutionary adaptations impact the phenotype differently. Hemoglobin analysis reveals that physiological changes affect specific parameters, while evolutionary changes affect others, suggesting distinct roles in adaptation.

Area of Science:

  • Biophysics
  • Evolutionary Biology
  • Physiological Adaptation

Background:

  • Physiological and evolutionary adaptations modify phenotypes across different timescales.
  • Quantitative analysis of the relationship between these adaptations is limited.
  • The hemoglobin molecule serves as a model to study these adaptive mechanisms.

Purpose of the Study:

  • To quantitatively analyze the relationship between physiological and evolutionary adaptations.
  • To investigate how these adaptations affect the hemoglobin molecule.
  • To understand the interplay between microscopic parameters modified by both types of adaptation.

Main Methods:

  • Comparing oxygen saturation curves of 25 mammal hemoglobins with human hemoglobin.
  • Utilizing the Monod-Wyman-Changeux model to extract microscopic parameters.

Related Experiment Videos

  • Analyzing data under a wide range of physiological conditions.

    • Main Results:

    • Physiological and evolutionary changes in hemoglobin act on distinct microscopic parameters.
    • The primary parameter altered by hemoglobin physiology remains constant during evolution.
    • The primary parameter altered by hemoglobin evolution remains constant during physiology.

    Conclusions:

    • Physiological and evolutionary adaptations of hemoglobin exhibit orthogonality.
    • This suggests ongoing selection for physiological adaptability.
    • Physiological adaptability may play a role in evolutionary change.