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The details bedevil DCOR.

J Silver1

  • 1Minerva Center for Calcium and Bone Metabolism, Nephrology and Hypertension Services, Hadassah Hebrew University Medical Center, Jerusalem, Israel. silver@huji.ac.il

Kidney International
|October 19, 2007
PubMed
Summary
This summary is machine-generated.

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New oral phosphorus binders like sevelamer hydrochloride offer promise for chronic kidney disease patients. However, the DCOR study found no clear superiority over calcium-based binders for dialysis patients.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Pharmacology

Background:

  • Calcium-free oral phosphorus binders, such as sevelamer hydrochloride, were introduced for chronic kidney disease (CKD) patients.
  • These binders aimed to reduce cardiovascular disease (CVD) morbidity and mortality in CKD patients.

Discussion:

  • The Dialysis Clinical Outcomes Revisited (DCOR) study compared sevelamer hydrochloride with calcium-based phosphorus binders.
  • The study evaluated the effects of these binders in dialysis patients.

Key Insights:

  • The DCOR study did not demonstrate a clear superiority of sevelamer hydrochloride over calcium-based phosphorus binders.
  • This finding challenges the initial expectations for calcium-free binders in improving patient outcomes.

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Outlook:

  • Further research is needed to clarify the comparative effectiveness of different phosphorus binders.
  • Optimizing phosphorus binder therapy remains crucial for managing CKD complications.