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Updated: Jul 10, 2026
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Estrogen-Like Effect of Bazi Bushen Capsule in Ovariectomized Rats
Published on: April 7, 2023
Experimental study on the estrogen-like effect of boric Acid
Yadong Wang1, Yingzheng Zhao, Xiaoyu Chen
1Department of Toxicology, Zhengzhou University of Henan, No. 100 Science Road, 450001 Zhengzhou, People's Republic of China.
Biological Trace Element Research
|October 19, 2007
Summary
Boric acid shows estrogen-like effects in vivo, increasing uterine weight and mucous membrane cell height. However, it does not impact serum estradiol levels or stimulate breast cancer cell proliferation.
Area of Science:
- Toxicology
- Endocrinology
- Reproductive Science
Background:
- Boric acid is linked to reproductive and developmental toxicity.
- The mechanism, specifically an estrogen-like effect, remains unclear.
Purpose of the Study:
- To investigate the potential estrogen-like effects of boric acid.
Main Methods:
- MCF-7 cell proliferation assay
- Uterotrophic assay in ovariectomized rats
- Estradiol (E2) level measurement
- Mucous membrane cell proliferation assay
- Estrogen receptor density assay
Main Results:
- Boric acid increased uterine weight and mucous membrane cell height in rats.
- It enhanced proliferating cell nuclear antigen expression and reduced estrogen receptor density.
- Boric acid did not alter serum estradiol levels or stimulate MCF-7 cell proliferation.
Conclusions:
- Boric acid demonstrates estrogen-like effects in vivo.
- The observed effects occur through mechanisms independent of direct estradiol interaction or MCF-7 cell stimulation.
