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Updated: Jul 10, 2026

Multidisciplinary Approach to Obesity Management: A Case Report

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

Infections and obesity: A multinational epidemiological study.

Bjarni Thjodleifsson¹, Isleifur Olafsson, Davíd Gislason

¹Department of Medicine, Landspitali University Hospital Hringbraut, IS-101, Reykjavik, Iceland. bjarnit@landspitali.is

Scandinavian Journal of Infectious Diseases

|October 19, 2007

Summary

Infections with Helicobacter pylori and Chlamydia pneumoniae are linked to overweight in a large population study. These infections showed a combined effect, suggesting a synergistic association with higher body mass index (BMI).

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Last Updated: Jul 10, 2026

Multidisciplinary Approach to Obesity Management: A Case Report

Multidisciplinary Approach to Obesity Management: A Case Report

Published on: May 30, 2025

Area of Science:

Infectious Diseases
Epidemiology
Obesity Research

Background:

Viral infections are implicated in obesity etiology in animal models.
The link between specific infections and human obesity requires further investigation.
Understanding these associations can inform public health strategies.

Purpose of the Study:

To investigate the association between serological markers of seven infections and body mass index (BMI).
To explore the synergistic effects of combined infections on BMI.
To examine the relationship between systemic inflammation markers and these associations.

Main Methods:

Population-based study of 985 individuals from Iceland, Sweden, and Estonia.
Measurement of IgG antibodies against Helicobacter pylori, hepatitis A virus, Toxoplasma gondii, herpes simplex virus 1, Chlamydia pneumoniae, Epstein-Barr virus, and cytomegalovirus.
Assessment of high-sensitive C-reactive protein (CRP) as a marker of systemic inflammation.

Main Results:

Significant positive associations were found between overweight (BMI ≥ 25 kg/m²) and IgG antibodies for Helicobacter pylori (OR 1.86) and Chlamydia pneumoniae (OR 1.39).
Combined seropositivity for these two infections showed a synergistic effect on overweight (OR 2.54).
CRP was positively related to BMI, but no significant association was found between CRP and IgG antibodies for Helicobacter pylori and/or Chlamydia pneumoniae.

Conclusions:

Infections with Chlamydia pneumoniae and Helicobacter pylori are significantly and synergistically associated with overweight.
This association is independent of systemic inflammation indicated by CRP levels.
Findings suggest specific microbial agents may play a role in human obesity.