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Published on: October 18, 2024
Low-dose aspirin for in vitro fertilisation
V J Poustie1, S Dodd, A J Drakeley
1Royal Liverpool Children's Hospital NHS Trust, Institute of Child Health, University of Liverpool, Eaton Road, Liverpool, Merseyside, UK, L12 2AP. v.poustie@liv.ac.uk
The Cochrane Database of Systematic Reviews
|October 19, 2007
Summary
Low-dose aspirin use in in vitro fertilisation (IVF) is not recommended due to insufficient evidence. More high-quality trials are needed to determine its effectiveness and safety for improving IVF outcomes.
Area of Science:
- Reproductive Medicine
- Clinical Trials
- Pharmacology
Background:
- Low-dose aspirin is sometimes used in in vitro fertilisation (IVF) cycles.
- Evidence for its efficacy is inconsistent, and potential side effects are a concern.
- Optimal timing and duration of aspirin therapy remain undetermined.
Purpose of the Study:
- To evaluate the effectiveness of low-dose aspirin in improving outcomes of IVF and intracytoplasmic sperm injection (ICSI) treatments.
- To synthesize evidence from randomized controlled trials on low-dose aspirin for women undergoing assisted reproductive technologies.
Main Methods:
- Systematic review of prospective randomized controlled trials (RCTs).
- Searches conducted across multiple databases (Cochrane, MEDLINE, EMBASE) up to March 2007.
- Inclusion criteria focused on RCTs addressing low-dose aspirin use in IVF/ICSI; quasi-RCTs were excluded.
Main Results:
- Nine eligible trials involving 1449 participants were analyzed.
- No significant differences were observed in live birth rates (RR 0.94, 95% CI 0.63-1.39) or clinical pregnancy rates (RR 1.09, 95% CI 0.83-1.43) between aspirin and control groups.
- No data on adverse events associated with aspirin treatment were reported in the included studies.
Conclusions:
- Current evidence from available trials does not support the recommendation of low-dose aspirin for women undergoing IVF.
- Further adequately powered RCTs are necessary to investigate aspirin's effects in diverse patient populations undergoing IVF.
- A sample size of 350 women per group is estimated to detect a 10% improvement in outcomes.
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