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Engineering of pharmaceutical materials: an industrial perspective
Kwok Chow1, Henry H Y Tong, Susan Lum
1Pharmaceutical Development Services, Patheon, Inc., 2100 Syntex Court, Mississauga, Ontario, Canada L5N 7K9. kwok.chow@patheon.com
Crystal engineering offers a strategic method for optimizing pharmaceutical formulations and processes by controlling solid-state properties. This review highlights its application in drug development, manufacturing technologies, and crystal modification strategies.
Area of Science:
- Pharmaceutical Science
- Materials Science
- Chemical Engineering
Background:
- Formulation, processing, and product performance issues in pharmaceuticals often stem from challenges with solid-state properties.
- Crystal engineering provides a systematic framework to address these challenges.
Purpose of the Study:
- To review the application of crystal engineering in manipulating solid-state properties of drugs and excipients.
- To discuss its role in successful pharmaceutical formulation and process development.
- To present existing and emerging manufacturing and co-processing technologies.
Main Methods:
- Literature review focusing on crystal engineering principles and their application in pharmaceuticals.
- Analysis of case studies illustrating crystal form design, selection, and modification.
- Discussion of relevant manufacturing and co-processing technologies.
Main Results:
- Crystal engineering enables rational control over solid-state properties, impacting drug formulation and processing.
- Successful examples of crystal form manipulation for improved pharmaceutical outcomes are presented.
- Current and novel manufacturing technologies are discussed in the context of crystal engineering.
Conclusions:
- Crystal engineering is a powerful tool for overcoming pharmaceutical development hurdles.
- Strategic manipulation of crystal forms is crucial for optimizing drug products.
- Integration of crystal engineering with advanced manufacturing technologies promises enhanced pharmaceutical development.
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