Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Human coronaviruses: what do they cause?

Lia van der Hoek1

  • 1Laboratory of Experimental Virology, Department of Medical Microbiology, Center for Infection and Immunity Amsterdam (CINIMA), Academic Medical Center of the University of Amsterdam, the Netherlands. c.m.vanderhoek@amc.uva.nl

Antiviral Therapy
|October 20, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Time to endemicity of SARS-CoV-2 in a sentinel cohort in the Netherlands: findings from a prospective observational study.

The Lancet. Microbe·2026
Same author

ICTV Virus Taxonomy Profile: <i>Anelloviridae</i> 2026.

The Journal of general virology·2026
Same author

Anellovirus constraint from 2 to 6 months postpartum followed by betatorquevirus and gammatorquevirus dominance in serum and milk.

Journal of virology·2025
Same author

Incidence of hepatitis C virus infection and associated determinants among men who have sex with men without HIV in Amsterdam, the Netherlands, between 2012 and 2021.

European journal of gastroenterology & hepatology·2025
Same author

Untreated HIV-1 infection and low CD4+ T cell counts and their effect on endemic human coronavirus (re)infection.

PLOS global public health·2025
Same author

VIDISCA-NGS in cerebrospinal fluid of adults with a suspected viral meningoencephalitis.

The Journal of infection·2025
Same journal

Safety and efficacy of deltoid intramuscular long-acting cabotegravir and rilpivirine, a case series.

Antiviral therapy·2026
Same journal

Factors associated with immunological non-response in HIV patients receiving antiretroviral therapy in Southeast Asia: A systematic review.

Antiviral therapy·2026
Same journal

Epidemiology and clinical management of cytomegalovirus infection in transplant recipients in Central and Eastern Europe - a physician survey.

Antiviral therapy·2026
Same journal

It's about time: The association between abacavir and cardiovascular disease.

Antiviral therapy·2026
Same journal

Combination antiviral and anti-CMV immunoglobulin therapy for CMV infection: A case-control study.

Antiviral therapy·2026
Same journal

Harnessing SuperNatural database to identify VP35 inhibitors as anti-Ebola drug candidates: A multistage <i>In silico</i> study.

Antiviral therapy·2025
See all related articles

Four human coronaviruses, including SARS-CoV, HCoV-NL63, and HCoV-HKU1, are circulating globally. While SARS-CoV is a recent emergence, HCoV-NL63 and HCoV-HKU1 have long been present, causing respiratory infections similar to older strains like HCoV-229E and HCoV-OC43.

Area of Science:

  • Virology
  • Infectious Diseases
  • Public Health

Background:

  • Human coronaviruses (HCoVs) like HCoV-229E and HCoV-OC43 have long been known to cause respiratory illnesses.
  • Recent discoveries include SARS-CoV (2003), HCoV-NL63 (2004), and HCoV-HKU1 (2005).

Purpose of the Study:

  • To provide an overview of the current knowledge on four circulating human coronaviruses.
  • To differentiate between newly emerged and long-circulating HCoV strains in the human population.

Main Methods:

  • Literature review and synthesis of existing data on human coronaviruses.
  • Comparative analysis of epidemiological and clinical characteristics of different HCoV strains.

Main Results:

  • SARS-CoV is a recent introduction to humans, while HCoV-NL63 and HCoV-HKU1 have circulated for a long time.

Related Experiment Videos

  • HCoV-NL63 and HCoV-HKU1 are widespread respiratory viruses, prevalent in winter, with symptoms similar to HCoV-229E and HCoV-OC43.

    • Conclusions:

    • The emergence of new HCoV descriptions does not necessarily indicate a sudden increase in novel viral infections.
    • Four HCoV types (SARS-CoV, HCoV-NL63, HCoV-HKU1, HCoV-229E, HCoV-OC43) are currently circulating in the human population, with varying origins and epidemiological patterns.