Related Experiment Video
Updated: Jul 10, 2026
Multimodal Approach to Assess Bone Regeneration and Scaffold Performance
Published on: February 13, 2026
Histological and ultrastructural evaluation of bone around Bio-Oss particles in sinus augmentation
Aim:
The aim of the present study was to evaluate histological and ultrastructural features of bone surrounding Bio-Oss particles retrieved, in the same patient, 20 months and 7 years after sinus augmentation.
Materials And Methods:
A 54-year patient who needed sinus elevation before implant rehabilitation participated in this study. Two bone cores at two different times were harvested from a Bio-Oss regenerated sinus and processed for examination under light and transmission electron microscopy.
Results:
Under light microscopy, in the 20-month specimen, most of the particles were surrounded by a thin layer of newly formed bone; in the 7-year specimen there was mainly compact bone in direct contact with the particles. Under transmission electron microscopy, it was possible to characterize the bone-biomaterial interface; in the 20-month specimen an electron-dense layer was seen, whereas, almost no electron-dense lines were seen at the interface in the 7-year specimen.
Conclusions:
Bio-Oss particles did not interfere with bone-healing processes after sinus augmentation procedures and promoted new bone formation. This study can help clinicians to understand better the morphological characteristics of bone regeneration processes using Bio-Oss after 20 months and, most importantly, after a longer time of interaction with surrounding tissues.
