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Related Experiment Video

Updated: Jul 10, 2026

Recording and Analyzing Multimodal Large-Scale Neuronal Ensemble Dynamics on CMOS-Integrated High-Density Microelectrode Array
09:44

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A new neural imaging approach using a CMOS imaging device.

David C Ng1, Takashi Tokuda, Takuma Nakagawa

  • 1Graduate School of Materials Science, Nara Institute of Science & Technology, Takayama, Ikoma, Nara, Japan.

Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
|October 20, 2007
PubMed
Summary

Researchers developed a novel CMOS device for in vivo functional brain imaging in mice. This technology enables precise measurement of brain protease activity, offering a new method for neural imaging research.

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Area of Science:

  • Neuroscience
  • Biomedical Engineering
  • Medical Imaging

Background:

  • In vivo functional imaging is crucial for understanding brain activity.
  • Existing methods may have limitations in resolution or invasiveness.
  • Detecting specific biochemical activities, like protease presence, offers insights into neural function.

Purpose of the Study:

  • To develop and demonstrate a dedicated CMOS device for in vivo functional imaging of the mouse brain.
  • To utilize on-chip fluorescence imaging for deep brain structures.
  • To measure brain protease activity using a novel imaging approach.

Main Methods:

  • Designed and fabricated a 176 x 144 pixel array CMOS image sensor.
  • Employed a novel packaging process for the sensor.
  • Utilized an on-chip fluorescence imaging configuration.
  • Verified functional imaging by detecting serine protease activity using a fluorogenic substrate after kainic acid induction.

Main Results:

  • Successfully imaged deep within the mouse hippocampus.
  • Measured brain protease activity by detecting fluorescence signals.
  • Accurately determined the reaction onset of serine protease.
  • Demonstrated the efficacy of the CMOS device for in vivo neural imaging.

Conclusions:

  • The developed CMOS device provides a novel approach for in vivo functional neural imaging.
  • This technology allows for precise measurement of biochemical activity in deep brain regions.
  • The method offers a new tool for neuroscience research and diagnostics.