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Updated: Jul 10, 2026

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice
Published on: January 7, 2019
Ordinary differential equation models for ethanol pharmacokinetic based on anatomy and physiology
Jae-Joon Han1, Martin H Plawecki, Peter C Doerschuk
1School of Electrical & Computer Engineering, Purdue University, West Lafayette, IN 47907-2035, USA.
Abstract:
Physiologically-based pharmacokinetic (PBPK) models have been used to describe the distribution and elimination characteristics of intravenous ethanol administration. Further, these models have been used to estimate the ethanol infusion profile required to prescribe a specific breath ethanol concentration time course in a specific human being, providing a platform upon which other pharmacokinetic and pharmacodynamic investigations are based. In these PBPK models, the equivalence of two different peripheral tissue models are shown and issues concerning the mass flow into the liver in comparison with ethanol metabolism in the liver are explained.
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