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Updated: Jul 10, 2026
Lentiviral Vector Platform for the Efficient Delivery of Epigenome-editing Tools into Human Induced Pluripotent Stem Cell-derived Disease Models
Published on: March 29, 2019
Non-viral charge reversal vectors for pDNA delivery
Carla A H Prata1, Yougen Li, Dan Luo
1Dept. of Biomed. Eng., Boston Univ., MA 02215, USA. cprata@bu.edu
Abstract:
A synthetic vector that transform from a cationic to an anionic lipid intracellularly is described. This charge-reversal lipid was synthesized and characterized, including the supramolecular complex it forms with DNA. Enhanced gene transfection was observed using this synthetic vector compared to current cationic lipids.
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