Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A fast algorithm for low-resolution protein structure prediction.

Rajkumar Bondugula1, Dong Xu, Yi Shang

  • 1Dept. of Comput. Sci., Missouri Univ., Columbia, MO 65211, USA.

Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference
|October 20, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MUFOLD-DB: a processed protein structure database for protein structure prediction and analysis.

BMC genomics·2015
Same author

Advances in translational bioinformatics facilitate revealing the landscape of complex disease mechanisms.

BMC bioinformatics·2015
Same author

The I-TASSER Suite: protein structure and function prediction.

Nature methods·2014
Same author

Genome-wide expression analysis of soybean NF-Y genes reveals potential function in development and drought response.

Molecular genetics and genomics : MGG·2014
Same author

Classification of lung cancer using ensemble-based feature selection and machine learning methods.

Molecular bioSystems·2014
Same author

Resveratrol possesses protective effects in a pristane-induced lupus mouse model.

PloS one·2014
Same journal

Highly Articulated Robotic Probe for Minimally Invasive Surgery.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference·2010
Same journal

Combined peripheral and cortical neural stimulation in motor neurorehabilitation.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference·2008
Same journal

Embedded assessment algorithms within home-based cognitive computer game exercises for elders.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference·2008
Same journal

Digital signal processing of the wideband external pulse recorded during cuff deflation: a new way to measure blood pressure.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference·2008
Same journal

Immune cells detection of the in vivo rejecting heart in USPIO-enhanced magnetic resonance imaging.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference·2008
Same journal

wHospital: a web-based application with digital signature for drugs dispensing management.

Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference·2007
See all related articles

We present a novel protein structure prediction method using mini-threading to identify useful protein fragments. This approach significantly reduces prediction time to minutes, offering an efficient alternative to existing computational methods.

Area of Science:

  • Structural biology
  • Computational biology
  • Bioinformatics

Background:

  • Protein tertiary structure prediction is crucial for understanding protein function.
  • Existing methods for protein structure prediction are computationally intensive, often requiring hours or days.

Purpose of the Study:

  • To develop a novel, efficient approach for protein tertiary structure prediction.
  • To leverage fragment-based information from the Protein Data Bank (PDB) for improved prediction accuracy and speed.

Main Methods:

  • The proposed method utilizes a mini-threading concept to identify relevant protein fragments of variable lengths.
  • Spatial restraints are retrieved from identified fragments.
  • Multidimensional scaling and least-squares minimization are employed to construct coarse-grain structural models.

Related Experiment Videos

Main Results:

  • The method efficiently utilizes information available in the Protein Data Bank.
  • Protein tertiary structure prediction is achieved in a matter of minutes.
  • This represents a substantial time saving compared to traditional methods.

Conclusions:

  • The mini-threading approach offers a significantly faster and efficient method for protein tertiary structure prediction.
  • This advancement has the potential to accelerate research in structural biology and drug discovery.