Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

ChemBank: a small-molecule screening and cheminformatics resource database.

Kathleen Petri Seiler1, Gregory A George, Mary Pat Happ

  • 1Chemical Biology Program and Platform, Broad Institute of Harvard and MIT, 7 Cambridge Center, Cambridge, MA 02142, USA.

Nucleic Acids Research
|October 20, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Modeling development of tertiary lymphoid structures in pulmonary tuberculosis by 3D profiling and trajectory analysis.

bioRxiv : the preprint server for biology·2026
Same author

Feasibility of endocardial left bundle branch pacing in a 3-month-old with complete congenital atrioventricular heart block: A case report.

HeartRhythm case reports·2025
Same author

Author Correction: Diversity-oriented synthesis yields novel multistage antimalarial inhibitors.

Nature·2025
Same author

Sharing data from the Human Tumor Atlas Network through standards, infrastructure and community engagement.

Nature methods·2025
Same author

Addressing persistent challenges in digital image analysis of cancer tissue: resources developed from a hackathon.

Molecular oncology·2025
Same author

Integrating spatial profiles and cancer genomics to identify immune-infiltrated mismatch repair proficient colorectal cancers.

bioRxiv : the preprint server for biology·2024
Same journal

Correction to 'scSuperAnnotator: A platform for benchmarking comparison and visualizing automated cellular annotation methods for scRNA-seq data'.

Nucleic acids research·2026
Same journal

Correction to 'Differentiable partition function calculation for RNA'.

Nucleic acids research·2026
Same journal

Deployment of non-canonical splicing in tunicate genomes is mediated by divergent U2AF function and changing m6A modification in U1 and U6 snRNA.

Nucleic acids research·2026
Same journal

Bacillus subtilis DnaB forms multiple protein-protein interactions essential for DNA replication initiation.

Nucleic acids research·2026
Same journal

Multiple forms of protein-protein and DNA binding are exhibited by BrxC from the BREX phage restriction system.

Nucleic acids research·2026
Same journal

Biosynthesis of glycosylated 5-hydroxycytosine in the DNA of diverse viruses.

Nucleic acids research·2026
See all related articles

ChemBank is a public informatics environment providing freely available small molecule screening data and analysis tools. It aims to give life scientists access to valuable data previously limited to the private sector.

Area of Science:

  • Chemical Biology
  • Bioinformatics
  • Drug Discovery

Background:

  • Small molecule screening generates vast amounts of data.
  • Access to this data is often limited to the private sector.
  • Existing databases lack comprehensive raw screening data storage and rigorous experimental definitions.

Purpose of the Study:

  • To establish a public, web-based informatics environment for small molecule screening data.
  • To provide freely available data and resources for studying small molecules and their effects.
  • To enable life scientists to access and analyze previously private data.

Main Methods:

  • Development of a public, web-based informatics environment (ChemBank).
  • Storage of raw screening data with rigorous statistical hypothesis testing.

Related Experiment Videos

  • Metadata-based organization of screening experiments into projects and related assays.
  • Integration of analysis tools for studying relationships between small molecules and biological measurements.

    • Main Results:

    • ChemBank provides access to hundreds of thousands of small molecules and hundreds of assays.
    • The platform stores diverse measurements from cell-based assays treated with small molecules.
    • Analysis tools are continuously developed to study small molecule-cell measurement relationships.

    Conclusions:

    • ChemBank offers a unique resource for small molecule research.
    • The platform democratizes access to valuable screening data and analysis tools.
    • It facilitates research by providing unfettered access to previously private sector data.