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[Spurious hyperphosphatemia in multiple myeloma].

I Jarchovsky1, H Beitner, L Plavnick

  • 1Dept. of Medicine B, Hillel Jaffe Medical Center, Hadera.

Harefuah
|December 15, 1991
PubMed
Summary
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Extreme hyperphosphatemia in a multiple myeloma patient was a lab artifact. Monoclonal immunoglobulin interfered with phosphorus testing, leading to falsely high results.

Area of Science:

  • Clinical Chemistry
  • Hematology

Background:

  • Multiple myeloma is a plasma cell malignancy.
  • Hyperphosphatemia can cause severe health issues.

Observation:

  • A patient with Ig A-kappa multiple myeloma presented with extreme hyperphosphatemia (29 mg/dL).
  • The patient showed no clinical signs of hyperphosphatemia.

Findings:

  • The high phosphorus levels were spurious, caused by monoclonal immunoglobulin interference with the phosphomolybdate calorimetric assay.
  • Serum phosphorus normalized after protein removal and chemotherapy-induced paraprotein reduction.

Implications:

  • Recognizing this interference phenomenon is crucial to avoid unnecessary diagnostic tests and treatments.
  • This finding highlights the importance of considering dysproteinemia in unexplained laboratory abnormalities.

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