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A Sensitive Visual Method for the Detection of Hydrogen Sulfide Producing Bacteria
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Hydrogen sulphide and its therapeutic potential
1Ikaria Inc., 1616 Eastlake Ave East, Suite 340, Seattle, Washington 98102, USA. csaba.szabo@ikaria.com
Nature Reviews. Drug Discovery
|October 20, 2007
Summary
Hydrogen sulphide (H2S), a key signaling molecule, plays roles in cardiovascular and nervous systems. Research explores H2S
Area of Science:
- Biochemistry
- Physiology
- Pharmacology
Background:
- Hydrogen sulphide (H2S) is recognized as a crucial signaling molecule in the cardiovascular and nervous systems.
- H2S is endogenously produced from L-cysteine, primarily by cystathionine gamma-lyase and cystathionine beta-synthase.
Purpose of the Study:
- To overview the physiology and biochemistry of H2S.
- To summarize the therapeutic potential of H2S modulation in disease models.
Main Methods:
- Review of existing literature on H2S.
- Analysis of studies involving H2S production inhibitors and H2S donor compounds in animal models.
Main Results:
- Inhibitors and donors of H2S show significant effects in models of inflammation, reperfusion injury, and circulatory shock.
- H2S can induce reversible hypothermia and a suspended-animation-like state in rodents.
Conclusions:
- H2S is a vital signaling molecule with broad physiological roles.
- Modulating H2S offers potential therapeutic strategies for various diseases.
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