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Water-curable and biodegradable prepolymers.

H Kobayashi1, S H Hyon, Y Ikada

  • 1Research Center for Biomedical Engineering, Kyoto University, Japan.

Journal of Biomedical Materials Research
|December 1, 1991
PubMed
Summary
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Researchers developed new biodegradable polymers that solidify in contact with water for tissue adhesion. Incorporating hydrophilic units improved curing and degradation rates, showing minimal tissue reaction.

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Tissue Engineering

Background:

  • Biodegradable polymers are crucial for medical applications, requiring in situ formability and tissue adherence.
  • Existing materials often lack optimal curing and degradation profiles for in vivo use.

Purpose of the Study:

  • To synthesize novel esterurethane prepolymers for in situ curing and tissue adhesion.
  • To investigate the impact of polymer structure on curing, degradation, and tissue response.

Main Methods:

  • Synthesized hydroxyl-terminated biodegradable polyesters via D,L-lactide or copolymerization with epsilon-caprolactone.
  • Reacted polyesters with diisocyanates to create isocyanate-terminated prepolymers.
  • Evaluated in vitro and in vivo curing, hydrolysis, and degradation rates.

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Main Results:

  • Esterurethane prepolymers cured upon contact with water, forming degradable materials.
  • Hydrophilic units in the polymer backbone significantly enhanced curing and degradation rates.
  • The resulting polymers exhibited minimal adverse tissue responses.

Conclusions:

  • Biodegradable esterurethane prepolymers can be synthesized for in situ application in living tissues.
  • Optimizing hydrophilic content is key to achieving desirable curing and degradation characteristics.
  • These novel polymers show promise for biomedical applications requiring tissue adhesion and controlled degradation.