Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Gastrointestinal Motility Disorders

Gastrointestinal Motility Disorders

Gastrointestinal or GI motility disorders are characterized by irregular gastrointestinal tract movements, disrupting food transit from the mouth to the anus. They are caused by damage or dysfunction in gut muscles or nerves. These disorders can cause symptoms such as severe constipation, diarrhea, abdominal pain, and swallowing difficulties. Disorders can affect any segment of the GI tract and range widely in severity, from common conditions like GERD to life-threatening conditions like...

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy

This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
In gastric emptying studies, a meal's liquid and solid...

Gastric Motility

Gastric Motility

Gastric motility is the coordinated contraction and relaxation of stomach muscles that convert ingested food into chyme, a semi-liquid substance ready for further digestion in the intestines. The process begins with the vagus nerve inducing the relaxation of the smooth muscles in the fundus and body of the stomach, allowing these regions to expand and accommodate up to approximately 1.5 liters of food and liquid.
Peristaltic Waves and Chyme Formation
Upon food entry, the stomach initiates...

Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists

Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists

Serotonin, a crucial neurotransmitter synthesized by enterochromaffin cells, plays a cardinal role in regulating gastrointestinal (GI) motility. With over 90% of the body's total serotonin in the GI tract, its influence on digestive processes is profound. Serotonin is swiftly released upon various stimuli, such as food boluses or certain drugs, triggering intrinsic sensory neurons in the myenteric plexus and extrinsic vagal and spinal sensory neurons. This leads to the activation of the...

Enteric Nervous System: Regulation of GI Motor Activity

Enteric Nervous System: Regulation of GI Motor Activity

The Enteric Nervous System (ENS) plays a pivotal role in regulating gastrointestinal or GI motor activity. This complex network of nerves, deeply embedded within the gut wall, responds to changes in the gut environment and receives input from both the autonomic nervous system and the central nervous system. By doing so, the ENS operates various programs tailored to the body's nutritional status and needs.
During periods of fasting, the ENS initiates the migrating myoelectric complex, a program...

Drugs Affecting GI Tract Motility: Other Laxatives

Drugs Affecting GI Tract Motility: Other Laxatives

Laxatives are primarily used to alleviate constipation, a common gastrointestinal disorder characterized by infrequent bowel movements and difficulty passing stools. They work by various mechanisms to increase the volume or frequency of bowel movements. The primary modes of action of laxatives include increasing stool bulk, softening the stool, stimulating intestinal motility, and osmotically drawing water into the intestines.
Osmotic or saline laxatives, like magnesium hydroxide or milk of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Expert Clinical Consensus on Body Surface Gastric Mapping Phenotypes for Gastroduodenal Disorders: 'Auckland Classification' v1.0.

Neurogastroenterology and motility·2026

Same author

Validation of a Short-Form Fear of Food Questionnaire in Patients With Functional Dyspepsia and Gastroparesis.

Neurogastroenterology and motility·2026

Same author

Efficacy and Safety of Domperidone for Patients With Symptoms of Gastroparesis; Long-Term Results.

Neurogastroenterology and motility·2026

Same author

Predominant Symptom in Gastroparesis: Relationships to Quality of Life, Treatments, and Outcome.

Neurogastroenterology and motility·2026

Same author

Revisiting the Incidence of Tardive Dyskinesia With Oral Metoclopramide Use: A Real-World Epidemiology Study (2011-2020).

Neurogastroenterology and motility·2026

Same author

Review Article: Drug Approval for Gastroparesis-Suggestions for Improving the Process for Positive Results.

Alimentary pharmacology & therapeutics·2026

Search research articles

Related Experiment Video

Updated: Jul 10, 2026

Gastrointestinal Motility Monitor (GIMM)

Gastrointestinal Motility Monitor (GIMM)

Published on: December 1, 2010

The gastrointestinal motility laboratory.

Henry P Parkman¹, William C Orr

¹Gastroenterology Section, Department of Medicine, Temple University School of Medicine, Parkinson Pavilion, 8th Floor, 3401 North Broad Street, Philadelphia, PA 19140, USA. henry.parkman@temple.edu

Gastroenterology Clinics of North America

|October 24, 2007

Summary

This summary is machine-generated.

Gastrointestinal (GI) motility disorders cause common health problems and high costs. This article guides setting up a GI motility laboratory for accurate diagnosis and effective treatment plans.

More Related Videos

Using An In Vitro Tissue Perfusion System to Detect the Functional Activities of Isolated Intestinal Tubes in Real Time

Using An In Vitro Tissue Perfusion System to Detect the Functional Activities of Isolated Intestinal Tubes in Real Time

Published on: July 26, 2024

Related Experiment Videos

Last Updated: Jul 10, 2026

Gastrointestinal Motility Monitor (GIMM)

Gastrointestinal Motility Monitor (GIMM)

Published on: December 1, 2010

Using An In Vitro Tissue Perfusion System to Detect the Functional Activities of Isolated Intestinal Tubes in Real Time

Using An In Vitro Tissue Perfusion System to Detect the Functional Activities of Isolated Intestinal Tubes in Real Time

Published on: July 26, 2024

Area of Science:

Gastroenterology
Digestive Diseases
Clinical Laboratory Science

Background:

Abnormalities in gastrointestinal (GI) motor function are linked to prevalent clinical issues.
These GI motility dysfunctions result in substantial healthcare expenditures.
Accurate diagnosis and treatment planning for GI motility disorders are crucial.

Purpose of the Study:

To outline key concepts for establishing and managing a functional GI motility laboratory.
To emphasize the role of the GI motility laboratory in patient evaluation within gastroenterology.
To highlight the laboratory's importance in comprehensive digestive disease programs.

Main Methods:

The article focuses on the principles and practical aspects of GI motility laboratory setup.
It addresses the operational requirements for an efficient laboratory environment.
Concepts for effective patient evaluation protocols are discussed.

Main Results:

Establishing a dedicated GI motility laboratory is essential for specialized patient care.
Efficient laboratory operations facilitate accurate diagnosis of GI motility disorders.
A well-run laboratory supports the development of appropriate treatment strategies.

Conclusions:

The GI motility laboratory is a vital component of modern gastroenterology practice.
Properly equipped and managed laboratories improve diagnostic yield and patient outcomes.
Investment in GI motility laboratory infrastructure is key for digestive disease management.